Nephrology © 2012 Asian Pacific Society of Nephrology. Heterogeneity and publication bias across the studies were also explored. Pooled analysis and multivariable meta-regression were calculated by random effects models. All data were analyzed by RevMan 5.1 and SPSS 17.0. Further, this meta-analysis may provide important clues for animal experiments even for human clinical trials in MSC studies. These, were indexed from PubMed and Embase databases. MSCs might get obvious effect in the early stage of renal injuries after arterial delivery. The present meta-analysis confirmed that MSC therapy could improve impaired renal function. Subgroup analysis showed there tended to be greater reduction in Scr with higher MSC number (>10(6)), the renal ischemia-reperfusion injury (IRI) model, and late administration (>1 day) after injury. By exploratory multivariable meta-regression, significant influence factors of Scr reduction were the time point of Scr measurement (early measurement showed greater reduction than the late (P = 0.005)) and the route of MSC delivery (arterial delivery of MSCs caused greater reduction in elevated Scr, when compared with the intra-renal delivery and intravenous injection (P = 0.040)).
REVMAN 5 META REGRESSION SOFTWARE
Review Manager 5 (RevMan 5) is the software that is used for preparing and. Sixty-five studies (57 with adults 8 with children) were included in the present meta-analysis. Many researchers now use logistic regression analysis to estimate the Odds.
The results of funnel plots and meta-regression were analyzed by the CMA 2.0 software. Pooled analysis showed elevated serum creatinine (Scr) reduction in the animal models of renal failure following MSC therapy. RevMan 5.3 software was used to calculate the crude mean difference (MD) and 95 confidence interval (CI). Accordlingly, the results for the random effects meta-analysis using the Mantel-Haenszel or inverse variance method are typically very similar. Heterogeneity and publication bias across the studies were also explored. Following RevMan 5, the Mantel-Haenszel estimator is used in the calculation of the between-study heterogeneity statistic Q which is used in the DerSimonian-Laird estimator. These, were indexed from PubMed and Embase databases. The meta-analysis of recent small animal experiments of mesenchymal stem/stromal cells (MSC) therapy for impaired kidney could provide significant clues to design large animal experiments as well as human clinical trials.Ī total of 21 studies was analyzed.
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